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KMID : 0644120050180030054
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Journal of Oriental Gynecology
2005 Volume.18 No. 3 p.54 ~ p.71
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Effect of Saururi Herba Seu Rhizoma on anti-inflammatory properties in RAW264.7 cell line and murine models of inflammation
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Kim Eui-Il
Kim Soo-Min
Lee Jung-Eun
Yoo Dong-Youl
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Abstract
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Purpose : The purpose of this research was to investigate the effects of Saurui Herba Seu Rhizoma(SHSR) on Anti-inflammatory properties in Raw264.7 cell line and murine models of inflammation.
Methods : To investigate the effects of Saurui Herba Seu Rhizoma(SHSR) on anti-inflammation, we study cytotoxicity effects of SHSR on Mouse Lung Fibroblast Cells and Peritoneal Macrophages, Inhibitory effects of SHSR on the nitric oxide (NO) release, the ROS production, and the interleukin-6 production.
Results : The cytotoxicity of SHSR on mouse lung fibroblast Cells and Raw264.7 cell line was not observed. SHSR in RAW264.7 cell line inhibited IL-1{beta}, IL-6 mRNA gene expression depending upon the concentrations of extract and inhibited IL-18 mRNA gene expression at 100 {mu}g/ml of extract. SHSR in RAW264.7 cell line inhibit COX-2 mRNA gene expression at 100, 10 {mu}g/ml of extract. SHSR in RAW264.7 cell line inhibited NOS-II mRNA gene expression depending upon the concentrations of extract. SHSR in RAW264.7 cell line didn’’t inhibit TNF-{alpha} mRNA gene expression. SHSR in RAW264.7 cell line decreased IL-6 production depending upon the concentrations of extract. SHSR in RAW264.7 cell line decreased ITNF-{alpha} production according to the concentrations of extract. SHSR in RAW264.7 cell line inhibited NO release specially SHSR 100, 10 {mu}g/ml concentrations of extract. SHSR inhibit ROS production depending upon the concentrations of extract.
Conclusion : These results suggest that SHSR can be used treating a lot of women disease caused by inflammation.
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KEYWORD
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Saururi Herba Seu Rhizoma, Anti-inflammation, women, inflammation
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